Treatment of Lentigo Maligna (Melanoma In Situ) With the Immune Response Modifier Imiquimod
نویسندگان
چکیده
منابع مشابه
Treatment of lentigo maligna (melanoma in situ) with the immune response modifier imiquimod.
BACKGROUND Surgical excision is the treatment of choice for lentigo maligna (LM), or melanoma in situ. Topical application of imiquimod, a local immune response modifier, is a novel therapeutic approach that leads to LM tumor clearance. This pilot, open-label, nonrandomized study evaluates the efficacy of imiquimod in patients with LM and other systemic problems that make them poor surgical ris...
متن کاملTreatment of lentigo maligna with topical imiquimod.
A published case report and anecdotal experience suggested that topical imiquimod is an effective treatment for stage 0 melanoma (lentigo maligna). To gauge the efficacy of this therapy, we undertook a trial of topical imiquimod in 30 subjects with histologically confirmed lentigo maligna. Thirty subjects with lentigo maligna were recruited for an open-labelled efficacy trial with daily topical...
متن کاملTreatment of lentigo maligna and lentigo maligna melanoma.
Thirty-eight cases of lentigo maligna and 22 cases of lentigo maligna melanoma, were reviewed in order to compare cure rates of various methods of treatment. Surgical excision resulted in the best cure rate (91%); destructive modalities were less successful (45%). All lesions treated with 5% 5-fluorouracil recurred.
متن کاملTopical Imiquimod Treatment of Lentigo Maligna
Lentigo maligna (LM) is the in situ phase of lentigo maligna melanoma, which may progress to invasive melanoma if left untreated. It mainly occurs on sun-exposed areas of elderly patients. The lesions can be large and conventional surgery can be difficult, particularly on the face. Recent reports indicate that topical imiquimod 5% cream is effective in the treatment of LM. It may be an alternat...
متن کاملLentigo maligna and lentigo maligna melanoma.
Lentigo maligna (LM) is a pigmented lesion that occurs on the sun-exposed skin, particularly the head and neck areas, of an older patient. The lesion increases in size and at some point, often many years after its onset, may become lentigo maligna melanoma (LMM). For this reason, most authors consider LM a form of melanoma in situ. Treatment includes surgical or destructive modalities; the pref...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2005
ISSN: 0003-987X
DOI: 10.1001/archderm.141.4.510